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EASL 2014: MK-5172 + MK-8742 Demonstrate Good Early Post-Treatment Response Rates

A combination of 2 direct-acting antivirals, MK-5172 and MK-8742, with or without ribavirin, led to early post-treatment sustained response rates above 90% for genotype 1 hepatitis C patients, including people with cirrhosis or HIV/HCV coinfection, according to a series of presentations last week at the 49th EASL International Liver Congress in London.

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EASL 2014: AbbVie 2-Drug Combo + Ribavirin Cures 100% of Previously Untreated HCV Genotype 4

A combination of two direct-acting antivirals developed by AbbVie cured 100% of previously untreated patients with hepatitis C genotype 4 infection when used with ribavirin, as well as all treatment-experienced patients followed for 4 weeks post-treatment, Christophe Hézode of Hôpital Henri Mondor in Paris reported at the 49th EASL International Liver Congress last week in London.

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EASL 2014: Sofosbuvir + Ribavirin Safe and Effective for Hepatitis C Patients with Advanced Liver Disease

Sofosbuvir (Sovaldi) plus ribavirin is a safe option that can lead to sustained response for people with advanced liver disease including those with decompensated cirrhosis and portal hypertension and patients who experience severe hepatitis recurrence after a liver transplant, researchers reported last week at the 49thEASL International Liver Congress in London.

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EASL 2014: BMS Dual Combo Cures 90% of Genotype 1b Hepatitis C in 24 Weeks

A combination of 2 direct-acting antivirals developed by Bristol-Myers Squibb (BMS), daclatasvir and asunaprevir, cured 90% of previously untreated people with genotype 1b hepatitis C in 24 weeks, without the need for pegylated interferon or ribavirin, Michael Manns of Hannover Medical School reported at the 49thEASL International Liver Congress (EASL 2014) in London last week.

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EASL 2014: Chinese Herbal Compound Inhibits Hepatitis C Virus Replication

SBEL1, a compound derived from a plant used in Chinese herbal medicine, has been shown to have activity against hepatitis C virus (HCV) replication in human liver cells in a laboratory study, according to a late-breaker poster presentation at the 49thEASL International Liver Congress (EASL 2014) last week in London.

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