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AIDS 2012: Novel PzMA Tuberculosis Combo Shows Potent Activity in Short-term Trial

A triple-combination regimen consisting of the experimental tuberculosis (TB) drug PA-824, the established TB drug pyrazinamide, and the widely used antibiotic moxifloxacin -- dubbed PaMZ -- showed potent bactericidal activity in a randomized 14-day study presented last week at the XIX International AIDS Conference (AIDS 2012) in Washington, DC, and published simultaneously in the July 23, 2012 issue of The Lancet.

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Advocates Release Updated Report on Pipeline Drugs for HIV, Hepatitis C, and TB

Drugs are HIV are more effective and plentiful than ever, but in many cases they are not making it into the hands of people who need them, according the 2012 Pipeline Report, released July 21 by HIV i-Base and the Treatment Action Group (TAG). Development of new direct-acting agents for hepatitis C, however, is occurring at a rapid pace.alt

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Novel Antibiotic Delamanid Is Effective against Multidrug-resistant Tuberculosis

An experimental antibiotic drug, delamanid (OPC-67683), demonstrated good activity against highly-resistant tuberculosis (TB), clearing infection in more than 40% of participants in a Phase 2b trial, researchers reported in the June 7, 2012, New England Journal of Medicine. The drug is currently being studied in HIV positive people taking antiretroviral therapy (ART).

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Janssen Requests FDA Approval of Bedaquiline (TMC207) for Multidrug-resistant TB

Janssen Research & Development this week submitted a New Drug Application requesting U.S. Food and Drug Administration (FDA) accelerated approval of bedaquiline (formerly TMC207), which would be the first drug for difficult-to-treat multidrug-resistant tuberculosis (MDR-TB).

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March 24 is World TB Day

Tuberculosis (TB) is the leading cause of death for people with HIV worldwide -- killing approximately 350,000 people in 2010 -- and the second leading cause for the population as a whole. Globally, an estimated 12 million people are living with latent TB. In the U.S., more than 10,500 new TB cases were reported in 2011, mostly in HIV negative people. Multidrug-resistant (MDR), extensively drug-resistant (XDR), and totally drug-resistant (TDR) TB are a growing concern.

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