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March 24 Is World TB Day

March 24 is World TB Day, an opportunity to raise awareness about tuberculosis (TB) and the need for expanded testing and treatment worldwide. The World Health Organization's theme for 2016 is "Unite to End Tuberculosis". Ending TB by 2030 is a target of the United Nations' Sustainable Development Goals.

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Isoniazid Alone Prevents TB in People with Advanced HIV, Urine Test May Cut Mortality

Using isoniazid alone to prevent the development of active tuberculosis (TB) in people with advanced HIV disease was equally effective and better tolerated than a common 4-drug empirical TB regimen, according to a study published in the March 19 edition of The Lancet in advance of World TB Day. Another study in the same issue found that a new inexpensive urine test has the potential to help reduce TB-related mortality by enabling faster treatment.

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CROI 2015: XDR TB Transmission in High-HIV-Prevalence Settings [VIDEO]

Most people with extensively drug-resistant tuberculosis (XDR-TB) in South Africa acquired the infection through person-to-person transmission -- including transmission in community settings as well as in hospitals -- rather than due to failure of treatment for multidrug-resistant TB, according to a report at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.

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CROI 2015: XDR-TB in South Africa is Largely Spread Person-to-Person, Not By Treatment Failure

The vast majority of people with extensively drug-resistant tuberculosis (XDR-TB) diagnosed in the world’s most extensive outbreak have acquired their infection from another person, not as the result of the failure of treatment for multidrug-resistant strains of tuberculosis (MDR-TB), N. Sarita Shah reported at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle.

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CROI 2015: Early ART and Isoniazid Preventive Therapy Reduce Risk of Illness and Death in Africa

Starting HIV treatment at a CD4 cell count above 500 cells/mm3 reduced the risk of serious illness, including tuberculosis (TB), and death by 44% when compared to starting treatment according to World Health Organization (WHO) guidelines, results from the 7-year Temprano study show. The findings were presented on at the 2015 Conference on Retroviruses and Opportunistic Infections (CROI) last week in Seattle. The study also found that a 6-month course of isoniazid preventive treatment (IPT) reduced the risk of developing TB by 35%.

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